鼠标点击后更改屏幕区域的颜色，并在发布Pygame后保持不变

，可以通过以下步骤实现：

导入所需的库和模块：

import pygame
from pygame.locals import *

初始化Pygame：

pygame.init()

设置屏幕的宽度和高度：

screen_width = 800
screen_height = 600
screen = pygame.display.set_mode((screen_width, screen_height))

定义颜色变量：

background_color = (255, 255, 255)  # 设置背景颜色为白色
clicked_color = (255, 0, 0)  # 设置点击后的颜色为红色

创建一个函数来处理鼠标点击事件：

def handle_click(pos):
    x, y = pos
    if x < screen_width / 2 and y < screen_height / 2:
        pygame.draw.rect(screen, clicked_color, (0, 0, screen_width / 2, screen_height / 2))
    elif x >= screen_width / 2 and y < screen_height / 2:
        pygame.draw.rect(screen, clicked_color, (screen_width / 2, 0, screen_width / 2, screen_height / 2))
    elif x < screen_width / 2 and y >= screen_height / 2:
        pygame.draw.rect(screen, clicked_color, (0, screen_height / 2, screen_width / 2, screen_height / 2))
    else:
        pygame.draw.rect(screen, clicked_color, (screen_width / 2, screen_height / 2, screen_width / 2, screen_height / 2))

创建一个主循环来处理事件和更新屏幕：

running = True
while running:
    for event in pygame.event.get():
        if event.type == QUIT:
            running = False
        elif event.type == MOUSEBUTTONDOWN:
            handle_click(pygame.mouse.get_pos())

    screen.fill(background_color)
    pygame.display.flip()