2024 AHA热点聚焦：8个最新科学研究，3个最新基础科学研究专场，共69项最新研究结果即将揭晓~

11月16日-18日，2024年美国心脏协会科学年会（2024 AHA）将在在芝加哥以线下+线上结合的方式召开。日前，大会议程已经公布，会议期间共设置8个最新科学研究专场（Late-Breaking Science，共29项最新研究）和3个最新基础科学研究专场（Late Breaking Basic Science, 共40项研究）。在今年的AHA大会上，即将会揭晓哪些重磅研究结果呢？一起先睹为快吧！

最新科学研究

（Late-Breaking Science，LBS）

LBS.01 庆祝心血管科学百年：从预防到治疗，再到治愈

北京时间：11月16日 21:30~22:45

BPROAD - Effects of Intensive Blood Pressure Control in Patients with Type 2 Diabetes (BPROAD)

BPROAD试验：强化血压控制对2型糖尿病患者的影响

SUMMIT - Tirzepatide for Patients With Heart Failure With Preserved Ejection Fraction and Obesity: the SUMMIT Trial

SUMMIT试验：替尔泊肽用于合并肥胖的射血分数保留型心力衰竭患者的治疗 Nexiguran ziclumeran (nex-z, also known as NTLA-2001), an investigational in vivo CRISPR-based therapy for patients with transthyretin amyloidosis with cardiomyopathy (ATTR-CM): interim report of the Phase 1 study

Nexiguran ziclumeran 1期研究中期报告：Nexiguran ziclumeran用于治疗合并转甲状腺素蛋白淀粉样变心肌病（ATTR-CM）患者的疗效和安全性

LBS.02 重新定义心律失常治疗：突破界限

北京时间：11月17日 02:30~03:45

VANISH2 - Catheter Ablation or Antiarrhythmic Drugs for Ventricular Tachycardia in Ischemic Cardiomyopathy (VANISH2)

VANISH2试验：缺血性心肌病室性心动过速的导管消融或抗心律失常药物治疗

OPTION - Randomized Comparison of Left Atrial Appendage Closure with Oral Anticoagulation after Catheter Ablation for Atrial Fibrillation (OPTION)

OPTION试验：房颤导管消融术后左心耳封堵 vs 口服抗凝药的随机对照试验

BRAIN AF - Blinded Randomized trial of Anticoagulation to prevent Ischemic stroke and Neurocognitive impairment in Atrial Fibrillation (BRAIN AF)

BRAIN AF试验：房颤患者进行抗凝治疗预防缺血性卒中和神经认知障碍的盲法随机试验

LBS.03 智能心脏病学：利用人工智能（AI）和创新改善心脏健康

北京时间：11月17日 04:15~05:30

PHARM-HF A&F - Evaluation of Randomized Audit and Feedback to Increase Heart Failure Medication Optimization Among Primary Care Pharmacists in the Veterans Affairs Health Care System (PHARM-HF A&F Study)

PHARM-HF A&F 试验：对退伍军人事务部医疗保健系统中的初级保健药剂师进行随机审核和反馈，以提高心衰用药优化的评估试验

SEISMIC HF-I - Novel AI to Assess Intracardiac Filling Pressure: The Non-invasive SEISMocardiogram In Cardiovascular Monitoring for Heart Failure I (SEISMIC-HF I) Study

SEISMIC-HF I试验：评估心内充盈压的新型AI技术——无创心震图（SCG）在心衰患者心血管监测中的应用

AI-ECHO - Artificial Intelligence-based Automated ECHOcardiographic Measurements and the Workflow of Sonographers (AI-ECHO): Randomized Crossover Trial (Accepted, not confirmed at time of publication)

AI-ECHO随机交叉试验：基于AI的自动超声心动图测量和超声技师的工作流程（已接受，发表时尚未确认）

PanEcho: Complete AI-enabled echocardiography interpretation with multi-task deep learning

PanEcho试验：通过多任务深度学习实现完整的AI超声心动图解读

LBS.04 从干预到预防：冠心病和瓣膜性心脏病研究进展

北京时间：11月17日 21:00~22:15

GLORIOUS - Efficacy of Restrictive versus Liberal Oxygenation in Patients undergoing Coronary Artery Bypass Grafting or Aortic Valve Replacement – a randomized clinical trial (GLORIOUS)

GLORIOUS随机临床试验：在冠状动脉旁路移植术（CABG）或主动脉瓣置换术（AVR）患者中，比较限制性吸氧与自由性吸氧的疗效

Efficacy of a Glucagon-Like Peptide-1 Agonist in Patients undergoing Coronary Artery Bypass Grafting or Aortic Valve Replacement – a randomized clinical trial (GLORIOUS)

GLORIOUS随机临床试验：GLP-1受体激动剂在进行CABG或AVR患者中的疗效

ENBALV - Efficacy and Safety of Edoxaban in Anticoagulant Therapy Early after Surgical Bioprosthetic Valve Replacement: ENBALV trial

ENBALV试验：进行外科生物瓣膜置换术的患者在早期应用艾多沙班进行抗凝治疗的有效性和安全性

The CLEAR SYNERGY (OASIS 9) Trial: A 2x2 Factorial Randomized Controlled Trial of Colchicine versus placebo and Spironolactone versus placebo in Patients with Myocardial Infarction. The results of the spironolactone factorial.

OASIS 9试验：秋水仙碱 vs. 安慰剂和螺内酯 vs. 安慰剂在心肌梗死患者中的2×2析因随机对照试验

LBS.05 预防创新与全球实施

北京时间：11月18日 04:30~05:45

TOPSPIN - A Three-arm Randomized Trial For Treatment Optimisation Of Blood Pressure With Single-pill Combinations In India

TOPSPIN试验：在印度患者中应用单片复方制剂优化血压控制的三臂随机试验

NUDGE-FLU - Electronic Nudges to Increase Influenza Vaccination among Patients with History of Myocardial Infarction: Insights from 3 Randomized Clinical Trials Enrolling >2 Million Patients (NUDGE-FLU)

NUDGE-FLU试验：电子助推有助于提高既往心肌梗死患者的流感疫苗接种率：来自三项随机临床试验（200多万患者）的见解

ZODIAC -  Pragmatic Randomized Controlled Trial of a Decision Support System to Aid Physician Optimization of Early Lipid Lowering Therapies after Acute Coronary Syndrome (ZODIAC)

ZODIAC试验：决策支持系统是否有利于辅助医生优化急性冠脉综合征后早期降脂治疗的实用随机对照试验

MHYH - Preliminary Results of Randomized Trial of New Versus Reconditioned Pacemakers for Patients Unable to Obtain a New Device in Low and Middle-Income Countries: The My Heart Your Heart (MHYH) Randomized Trial

MHYH随机试验：在中低收入国家无法获得新设备的患者中，进行新型起搏器和修复起搏器的随机试验的初步结果

LBS.06 以四大支柱为基础：心力衰竭药物治疗的新试验

北京时间：11月18日 21:00~22:15

ENDEAVOR - Myeloperoxidase Inhibition with Mitiperstat in Heart Failure with Preserved and Mildly Reduced Ejection Fraction: Primary Results from the ENDEAVOR Randomized Clinical Trial