中医药小分子和表观遗传重编程

tags: #小分子重编程 #表观遗传 #生物黑客 #中医药

OSKM

OSKM是Oct4, Sox2, Klf4, and c-Myc的缩写，由于诱导c-Myc有致癌性，一般诱导OSK。

灵芝诱导OCT4

灵芝烯酸B诱导Oct4去SUMO化激活G0期胃癌侧群细胞

http://www.tjzhongyiyao.com/html/tjzyy/2019/4/20190421.htm CHENG Ruizhen, ZHANG Chunyan, LIU Fengting, LI Rui, WU Wenjing, LI Yanxia, MA Xiaofang, LI Lili, LIU Xiaozhi. Ganoderma acid B induces Oct4 deSUMOylation and activates gastric cancer side population cells in G0 phase. Tianjin Journal of Traditional Chinese Medicine, 2019, 36(4): 396-399.

人参诱导SOX2

人参皂苷维持衰老神经干细胞生物学特性的作用 - CNKI

人参皂苷可以促进老化NSCs中SOX2和BMI-1表达增加,证明人参皂苷能维持和增强衰老神经干细胞生物学特性,与人参延缓脑老化的临床作用密切相关。

白藜芦醇诱导Klf4

白藜芦醇诱导Klf4

Resveratrol enhanced the expression of pluripotency of mouse embryonic stem cells and increased the pluripotency markers Oct3/4, Sox2, Nanog, and Klf4 by activating the AMPK/Ulk1 pathway [104].

文献信息

Wang C, Ling S, Xu J W. Effect of Active Ingredients of Chinese Herbal Medicine on the Rejuvenation of Healthy Aging: Focus on Stem Cells[J]. Evidence-Based Complementary and Alternative Medicine, 2020, 2020. https://www.hindawi.com/journals/ecam/2020/7307026/

鹿茸：抑制PERK

鹿茸提取物对血管性痴呆大鼠模型的治疗作用及其机制

董晗， 黄卫新， 胡亚男， 王越晖， 赵建军 - 临床与病理杂志, 2019 - lcbl.csu.edu.cn

… Western blot showed that the pilose antler extract could down-regulate the expression of PERK and EIf2α. Conclusion: Pilose antler extract has a certain therapeutic effect on VaD model in rats. Its mechanism may be related to the inhibition of PERK/EIf2α and the up-regulation …